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Published phase 3 trial data, including the OASIS 1 trial (Knop et al., 2023), show that high-dose oral semaglutide produced substantial body weight reduction at 68 weeks, with outcomes that approached those seen in injectable semaglutide trials, though these comparisons are not head-to-head

Initially focused on metabolism, research showed NNMT elevation with age/weight leads to fat accumulation, inefficiency, and NAD+ loss.[30][31] High NNMT correlates with insulin resistance and obesity in humans

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